Renal Microvascular Complications Of Type 2 Diabetes Essay

Renal Microvascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Abstract There have been a number of manuscripts reporting on the association of complications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed through 2000 using the NIH PubMed Literature Search System. Inclusion criteria were that manuscripts 1) be primary peer-review research article; 2) concisely explained, or investigated, the pathophysiology of renal microvascular complications in type 2 diabetes; 3) be published in English. High blood glucose levels and enhanced oxidative stress, found in both clinical and experimental diabetes, are thought to be the main cause of chronic diabetic complications. Advanced glycation end products (AGEs) resulted to be strongly correlated to renal microvascular complications via enhanced expression of adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1). Renal Microvascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Diabetes mellitus type 2 is a complex disease withShow MoreRelatedInvestigating The Aetiology And Pathophysiology Of Renal Microvascular Complications1094 Words   |  5 Pages There have been a number of manuscripts reporting on the association of complications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed through 2000 using the NIH PubMed Literature Search System. Inclusion criteriaRead MoreDiabetic Microvascular : Leading Cause Blindness762 Words   |  4 PagesDiabetic microvascular complications are the leading cause of blindness, end-stage renal diseases, and other neuropathies due to hypoxia and ischemia in the retina, the kidney, and nerves. Thickening of the capillary basement membrane result in decreased tissue perfusion. Many people with type 2 diabetes present with microvascular complications because of the long duration of asymptomatic hyperglycemia that usually precedes diagnosis (Mccaine and Huther). Diabetic Retinopathy Diabetic retinopathyRead MoreDiabetes Mellitus And The Long Term Complications1385 Words   |  6 Pagesthis paper is to give a general idea of diabetes mellitus, epidemiology, role factors and complications that arise from it, comparing and exhibiting the distinctions between type I type II diabetes, the people who are in jeopardy of developing diabetic renal diseases and hypertension due to the complications identifying the general pathogenesis of diabetes mellitus the long term complications that may transpire. Epidemiology of Diabetes Mellitus Diabetes Mellitus is one of the very prevalentRead MoreIntensive Glucose Control Of Patients With Type 1 Diabetes Mellitus Essay1606 Words   |  7 PagesTopic Intensive glucose control of patients with type 1 diabetes mellitus to maintain blood glucose levels (BGLs) near normal range Introduction Type 1 diabetes is an autoimmune disorder which can occur from insufficient insulin secretion. Insulin is a hormone which is secreted by the pancreas and regulates BGLs (Loghmani, 2005; Nussey Whitehead, 2001). Type 1 diabetes is also known as insulin dependent diabetes mellitus (IDDM). In this, the body produces no, or very little, insulin which canRead MoreType 2 Diabetes : An Overview Essay760 Words   |  4 PagesType 2 Diabetes: An Overview Diabetes mellitus is a disease that affects how an individual’s body metabolizes glucose (Blair, 2016; Franks, 2012; Scobie, McLean, Samaras, 2014; Spears, Schub, Pravikoff, 2015; WebMD, 2016c). People diagnosed with type 2 diabetes do not produce a sufficient amount of insulin to keep up with the demands of the body; which leads to hyperglycemia (Blair, 2016; Franks, 2012; Scobie et al., 2014; Spears et al., 2015; WebMD, 2016c). Glucose is the main source of energyRead MoreDiabetic Nephropathy Case Study1448 Words   |  6 PagesAim: Diabetic nephropathy (DN), classically defined by the presence of proteinuria is one of the major late microvascular complications of type 1 and type 2 diabetes mellitus and leading to a decline in renal function. In the present study, three important single nucleotide polymorphisms (SNPs) of the PPARG gene were analysed to understand the potential modifier effect of PPARG gene on the advancement of chronic kidney disease in DN. Methods: A total of 187 diabetic nephropathy patients (101 maleRead MoreThe Use of GLP 1 Analogues1608 Words   |  6 Pagesanalogues Patients with type 2 diabetes are at risk of macrovascular and microvascular complications. Evidence has shown that an improvement in blood glucose control, as shown by a reduction in HbA1c levels, is associated with a reduction in microvascular complications (2,3,4). Evidence from ACCORD (2), UKPDS(3) and ADVANCE(4) suggests that intensive blood glucose control reduced composite endpoints for microvascular outcomes, but the impact on patient oriented outcomes such as renal failure or dialysisRead MoreEssay On The Road To Health With Prediabetes1205 Words   |  5 Pagesbut not high enough to be diagnosed as type 2 diabetes. Despite advances in medical technology, treatments, and diagnoses, uncontrolled diabetes continues to rise in the United States (US) (American Diabetes Association [ADA], 2016). Between 2012-2014, 33.9 % of the US population were diagnosed with prediabetes (Center for Disease Control and Prevention [CDC], 2016). According to the ADA (2016) in 2010 18.8 million of the population was diagnosed with diabetes, 7 million were undiagnosed, comparedRead MoreUsing Sglt 2 Inhibitors With Insulin Essay729 Words   |  3 PagesUSING SGLT-2 INHIBITORS WITH INSULIN IN TYPE 2 DIABETES: CLINICAL IMPLICATIONS Mathew John, Deepa Gopinath Introduction Diabetes and its complications account for significant healthcare costs in developed countries. The control of hyperglycemia forms the cornerstone in managing diabetes. United Kingdom Prospective Diabetes Study (UKPDS) has shown that improving blood sugars can result in reduction in onset of retinopathy, microalbuminuria and neuropathy. Follow up of the subjects in UKPDS afterRead MoreHealth Disease Choice : Diabetes802 Words   |  4 PagesHealth Disease Choice - Diabetes Type 2 diabetes is one of the most common chronic conditions encountered in the primary care setting. It is a lifetime condition that requires careful management to prevent debilitating complications, such as peripheral neuropathy, amputations, diabetic nephropathy, kidney failure, diabetic retinopathy, and blindness. It is also a cardiovascular risk factor to heart attack and stroke. Basing on my experience with my patient encounters as a nurse, most diabetics do

High Noon Analysis - 938 Words

Honor, abstract in definition, is elucidated by communities and its individuals. It is a changing force, that can be approached from many different perspectives and has been interpreted countless ways. Honor used to be interpreted as a code that members of a community would follow in order to be recognized with esteem and respect. Over time, honor has been determined by the individual, regardless of other interpretations. An individual would build their honor manifesto on the values they deem necessary to live an honorable life, honorable according to their definition. In The Crucible, by Arthur Miller, John Proctor prioritizes love. Will Kane, from the film â€Å"High Noon†, directed by Fred Zinnemann, values responsibility. John Proctor and†¦show more content†¦He was the one that originally arrested and agitated Miller, therefore, he felt it was his responsibility to address the consequences. After he had killed Miller and the additional accomplices, thus completin g his personal mission, he was able to throw away the tin star and leave everything behind. That tin star symbolizes his job and the town, and by throwing it away, he demonstrates that he no longer cares or feels the need to stay. This display shows that the town, nor its inhabitants, were his source of motivation. He may have acted selflessly, but he did so for his own personal need of fulfilling his duty. Both characters developed a personal definition of honor, and both characters were rejected by their communities as result of living in accordance with their manifesto. The communities of Salem and Hadleyville, each community belonging to a unique time period and environment, has their own code of honor. However, both communities overlap in their need for self-preservation and greediness. In Salem’s case, when the witch trials erupted, many people, supposedly Mr. Putnam being one of them, and Abigail another took this as a chance to gain power and prey on those they hated. In fact, the overall community took it as a chance to spread hate and distrust. It was at this time, the community lackedShow MoreRelatedCritical Analysis of Film785 Words   |  4 PagesGive a critical analysis of the Western Holly Wood film High Noon. This essay will focus on the current representation of women and men in the classical Holly Wood western film High Noon, focusing on the gender roles of each character and the stereotypical roles that are given. High Noon  is a 1952 Western film  directed by  Fred Zinnemann, one which broke genre rules of masculine ideals and popular themes of cowboys and indians (Johans;1994). The male protagonist Marshal  Kane (Gary Cooper  ) startsRead MoreJ. Galsworthy. the Broken Boot1005 Words   |  5 PagesA Sample of Complex Stylistic Analysis J. Galsworthy. The Broken Boot (E.M. Zeltin et. Al. English Graduation Course, 1972, pp.88-89: finishing with the words .. .walked side by side.) Text Interpretation The passage under analysis is taken from John Galsworthys story The Broken Boot. It is about an actor whose name is Gilbert Caister. For six months he had been without a job and a proper meal. He ran into a man whom he had come to know in a convalescent camp, a man who thought aRead MoreJ. Galsworthy. the Broken Boot1021 Words   |  5 PagesA Sample of Complex Stylistic Analysis J. Galsworthy. The Broken Boot (E.M. Zeltin et. Al. English Graduation Course, 1972, pp.88-89: finishing with the words .. .walked side by side.) Text Interpretation The passage under analysis is taken from John Galsworthys story The Broken Boot. It is about an actor whose name is Gilbert Caister. For six months he had been without a job and a proper meal. He ran into a man whom he had come to know in a convalescent camp, a man who thought a lot ofRead MoreIndividual Report (50%)806 Words   |  4 Pagesmain features of the marketing plan. The new market that you recommend is your choice but it must not be one where the Company is already present. The report should be 3000 words max and the hand in date is 13th March 2013 via Blackboard before 12 noon. Your recommendation needs to contain the following: 1 Reasons for selection of new market for entry by the Company 2. Alternative markets which were candidates and reasons not selected 3 Proposed market entry strategy, including rationale Read MoreA Brief Note On Industrial And Organizational Psychology1819 Words   |  8 Pagesinsights on increasing productivity in the workplace and related matters such as physical and mental wellbeing of employees (Youssef Noon, 2012, sec.1.1). Industrial organizational psychology is known to be the most important asset in the organization, in which the factors are many; influence, performance, creation, strategies, innovation, and superiority (Youssef Noon, 2012, sec.1.1). These levels perform a wide variety of tasks in industrial/organization psychology involving studying worker attitudesRead MoreEssay On Eta1356 Words   |  6 Pagestake a wider Determination of dry and wet edges in the LST– NDVI scatter is necessary, to estimate pixel by pixel ET and EF using Eqs. (4) and (5). In arid and semi-arid areas, it should be noted that, for given vegetation cover, spatial pixels with high surface temperature and low EF are detectable by satellite remote sensors. On the other hand, the saturated soil water which evaporates potentially pixels is rarely and hardly existed in these conditions (see red lined triangle inside Fig. 2). 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Most Significant Events of Each Decade Free Essays

Most Significant Events Final Project K A University of Phoenix: Axia College Jonathan Tietz November 28, 2010 Most Significant Events of the 50`s, 60`s 70`s 80`s and 90`s World War II lasted from 1939 to 1945. This was a war that involved most of the world’s nations and all of the world’s greatest powers. When the war ended the events that followed over the next five decades had a great effect on the American people. We will write a custom essay sample on Most Significant Events of Each Decade or any similar topic only for you Order Now There are some events that had more of an effect than others. This paper will discuss five major events over five decades that has had a powerful effect on the American people.Beginning in 1950 and ending in 1990, this paper will discuss the most significant events from each decade that either positively or negatively changed the American way of living. The communist scare took place in the 1950`s. McCarthyism, named after a man named Joseph McCarthy was a republican U. S. senator. In the 1950`s anticommunism created fear among the American people (McCarthyism, 2006). McCarthy played on Americans fears in an effort to better his political campaign. He instilled this fear by convicting anyone who was a part of the communist party or had anything to do with it.During court hearing Americans remained silent so that they wouldn`t be accused of communism. He accused some of the United States federal government of being communist and soviet spies. McCarthy was unable to prove his claims and was therefore censored by the American government (McCarthyism, 2006). Americans lost their jobs if they were accused of communism, library books were burned to hide evidence of communist acts. Americans suffered greatly during this time as they had to walk on around on egg shells (McCarthyism, 2006). IfAmericans did not agree with anticommunism, they were considered to be communist and were punished for not supporting the American way. People feared McCarthy, but it all ended when he made a public mockery of senate procedures (McCarthyism, 2006). He ended his career to be known as reckless and dishonest man. Americans want peace took place in the 1960`s. The Vietnam War was well overdue considering some events that took place after World War II. How did America get involved in the Vietnam War? It all started with the Atlantic Charter. Franklin D. Roosevelt and Winston S.Church hill created this charter in hopes of a better world. Russia and China were not part of this charter and ultimately lead the U. S. to believe that Russia and China were involved in colonialism. Communism increased in South East Asia, mostly in Korea, Vietnam, China, and Cuba. The U. S. took action and attacked and conflict arose with Korea. The U. S. gets involved in Southeast Asia`s politics. North Korea invades South Korea. Nothing is accomplished and North Korea remains the same and South Korea remains the same. Next the U. S. inhabits South Vietnam.The U. S. helps rebuild South Vietnams economy. The U. S. tried to gain control over South Vietnams politics to avoid Vietnam turning communist. In 1965 North Vietnam attacked South Vietnam and American bases. North Vietnam lost the Vietnam War because they were no match for the American troops. The war had a dramatic effect on the American way of living. Americans rallied for peace and fell into the hippie era during the Vietnam War. During this time sex and drugs were on the rise. New drugs were introduced to the American people as the drug population grew.People began to have more sex during this time, which may have something to do with the increased drug use. The hippie era was a way of Americans expressing themselves of how they felt about the war. Many people wrote songs that told stories of things that were going on during that time. Mainly people wanted the war to end. Americans wanted peace, and sex, drugs and music was their way of getting away from it all. Detente took place in the 1970`s. Nixon`s visit to china in 1972 was an important step to build a relationship between America and China. This was the first time an American president had visited China.President Nixon visited China from February 21-28, 1972. Nixon reaffirmed interest for a peaceful settlement, and the U. S. continued to have relations with the Republic of China. Nixon was a strong advocate against communism so it surprised everyone when he went to visit china. He felt that if all nations cooperated with each other, then they could have reduced revenue and prevented a third world war. Nixon`s engagement with the communist was called Detente. Nixon held diplomatic conversations with China to establish a relationship and use that relationship against the Soviet Union.Nixon began the Nuclear Arms Reduction Treaty. Soon after came the end of the cold war. All About the Benjamin’s, took place in the 1980`s the decade of corporate greed. During this time Ronald Regan was the president and he was looking for a way to improve the American economy. His economic policy focused on focused on four points. First Regan wanted to reduce government spending, reduce income, reduce government regulation and control the money supply (Reagonomics 2010). His approach involved reducing tax cuts for wealthy Americans, and cutting funding for lower class Americans ( Reagonomics 2010).Regan felt if he cut funds for people on welfare that those Americans would try to get jobs. He introduced the earned income credit. He felt that this tax credit would be a way to encourage the unemployed to get out and work. Regan economic policies had both positive and negative effects on the American way of living (Reganomics 2010). The wealthy became richer and the poor became poorer. The unemployment rate declined but there was an increase in homeless and hungry Americans. Regan thought that he could create wealth for the U. S. by allowing business owners and free market corporations to compete for wealth.Reagan lowered the oil windfall profit tax. He lifted the petroleum price, deregulated airlines, and most of the airlines went bankrupt. He thought he could fix things that he could not fix. His motives were in the right place but the actions he took were not completely in the Americas best interest. Many Americans suffered during this time, but still Reagan was elected for a second term. He was liked by many. Some believe that Reganomics benefited America. Some of the policies introduced by Reagan are still being used today. Some of Reagan’s policies served as a blueprint on different ways to better the conomy. The Never Ending War took place in the 1990`s. In the books it is written that the gulf war began in August 1990 and ended in February 1991, but a war in Iraq still goes on today (1990`s, 2010). The gulf war was a war waged by the U. N. led by the United States and The United Nations against Iraq. Iraq troops invaded Kuwait in 1990 and brought immediate economic sanctions against Iraq. United States president George H. W. Bush sent American soldiers to Saudi Arabia six months later (1990`s, 2010). Many nations joined the coalition with America but America had the majority in military forces.Following The United States was Saudi Arabia, The United Kingdom, and Egypt (Gulf War, 2010). There had already been friction with Iraq and the United States that date back to the Cold War. Iraq was an ally of the Soviet Union (Gulf War, 2010). The United States had a concern involving Iraq`s position on Israel and Palestinian politics because Iraq disapproved of peace between Israel and Egypt. On August 12, 1990 Saddam Hussein wanted to compromise (Gulf War, 2010). He requested an immediate freeze of all boycott and siege decisions and wanted normalization of relations with Iraq.The United States expressed that there would be no negotiations until Iraq came out of Kuwait. Many resolutions were passed regarding the invasion made by Iraq. The most important was Resolution 678, passed in November of 1990, which set a deadline for Iraq to withdrawal from Kuwait (Gulf War, 2010). The deadline was for January 15, 1991. Ultimately if Iraq did not withdrawal but that time, they would have to be forced out. This brings us back to the coalition. Some countries did not join the coalition but sent money in support of it. Some countries did not want to increase U. S. nfluence in the Middle East (1990`s, 2010). In the end many nations were persuaded. Nations were promised economic aid, debt forgiveness or threats to withhold aid. Today the war in Iraq continues. There are still American troops overseas. How long will this war continue? It is unknown, but what is known is that this war has been indirectly been going on for decades, and all other wars and significant events before this war ultimately led to this one. So what is going to happen to America for the years to come? How will our current president deal with current issue that are results of past presidents decisions?America still has the same economic problems that Regan faced. We are still at war with Iraq even after the first President Bush left office. In the future I see the war continuing. After the attacks of 9/11 I don’t think that The United States government would feel comfortable if they pulled all of the soldiers out of Iraq. I see the United States falling into a deeper depression. After all we are dealing with years of economic recovery. The unemployment rate over the past years has dropped. It is extremely hard for some people to get jobs. What is so hard to understand is how the United States began as one of the strongest countries economically, socially and politically and now we are falling so far behind. The United States is falling behind in education and this used to be the leading country in education. The United States has fallen behind in production. How could a country that is not social developed, compete with other countries that are so far ahead? It is unknown where the United States will be a decade from now but based on the past compared to now, we might be dealing with same old issues.It may be worst. There may be more homeless, hungry, unemployed Americans a decade from now. The way the deficit is Funding for welfare programs may get cut again. Things are still the same. The rich are getting richer and the poor are getting poorer. If things do not soon change, there will be no hope for America’s future.Works CitedMcCarthyism. (2006, 8 23). Retrieved 11 23, 2010, from pbs. org: http://www. pbs. org/wnet/americanmasters/episodes/arthur-miller/mccarthyism/484/ 1990`s. (2010).Retrieved 11 28, 2010, from Wikipedia: http://en. wikipedia. org/wiki/1990s Gulf War. (2010).Retrieved 11 27, 2010, from Wikipedia: http://en. wikipedia. org/wiki/Gulf_War Vietnam War. (2010).Retrieved 11 23, 2010, from wikipedia: http://en. wikipedia.org/wiki/Vietnam_War How to cite Most Significant Events of Each Decade, Papers

Things Not Seen free essay sample

Things Not Seen Author: Andrew Clements Genre: Fiction Favorite Character amp; Why: My favorite character in this story was Robert Phelps also known as â€Å"Bobby†, because Bobby feels invisible to his parents, even before he actually is invisible. He feels like they put work before him, and don’t notice what he wants or who he is, which I can relate to. Reasons I liked this Book: The reasons I liked this book is because it shows how this teenager has to deal with being invisible and not knowing if he’ll ever go back to normal. Also because this book makes you think about how you would feel and deal with the fact knowing that you’re invisible and no one can see you. Summary: Fifteen year old Bobby Phillips wakes up one morning and discovers he’s become invisible. After he proves to his parents that je has turn invisible he is forced to stay at home and not to tell anyone that he has become invisible. We will write a custom essay sample on Things Not Seen or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Then Bobby’s parents get into a car accident that causes them to be hospitalized. So Bobby then meets a blind girl named Alicia in a library. And later on learns that about Bobby’s â€Å"condition† that he has. Later on the law gets involved and investigates why Bobby has not been seen, which could end up with his parents in jail. On this difficult journey that Bobby has to face with his parents and his new friend Alicia by his side to help him find out why he has become invisible. 1st Quote: I cant see myself! You cant see me. I cant be seen like, Im invisible! † (3) This quote is important because it shows how scared Bobby is and how he reacts to his parents about him not being able to see himself. This can give you an idea on how he will deal with him being invisible later on. 2nd Quote: â€Å"But then come the tears. Mom slumps down in her chair and starts crying, and I cant take that. I can never take that. †   (6) This shows how Bobby’ s Condition is begging to affect his mother.